Using together NMN and NR creates a potent approach to increase NAD+ levels. These synergistic NAD+ precursors leverage different absorption mechanisms - nicotinamide mononucleotide functions via the Slc12a8 transporter, while nicotinamide riboside works through NRK1 NRK2 enzymes. This NMN NR combination enhances mitochondrial function more effectively than single compounds.